Weaving together two parallel narratives, 'Witches' tells the story of Feliciana, an indigenous curandera or healer, and Zoe, a journalist: two women who meet through the murder of Feliciana's cousin Paloma. In the tiny village of San Felipe in Jalisco province, where traditional ways and traditional beliefs are a present reality, Feliciana tells the story of her life, her community's acceptance of her as a genuine curandera and the difficult choices faced by her joyful and spirited cousin Paloma who is both a healer and a Muxe - a trans woman. Growing up in Mexico City, Zoe attempts to find her way in a society straitjacketed by its hostile macho culture. But it is Feliciana's and Paloma's stories that draw her own story out of her, taking her on a journey to understanding her place in the world and the power of her voice.