1726. Surgeon John Howard is a rational man. His apprentice Zachary knows John is reluctant to believe anything that purports to exist outside the realm of logic. But even John cannot explain how or why Mary Toft, the wife of a local farmer, manages to give birth to a dead rabbit. When this singular event becomes a regular occurrence, John realises that nothing in his experience as a village physician has prepared him to deal with a situation as disturbing as this. He writes to several preeminent surgeons in London, three of whom quickly arrive in the small town of Godalming ready to observe and opine. When Mary's plight reaches the attention of King George, Mary and her doctors are summoned to London, where Zachary experiences for the first time a world apart from his small-town existence, and is exposed to some of the darkest corners of the human soul.