Nancy Skidmore has Alzheimer's and her oldest friend Eugene Chaney III once more a purpose in life - to end hers. When the moment for Gene to take Nancy to her desired death in Coffeeville arrives, she is unexpectedly admitted to the secure unit of a nursing home and he has to call upon his two remaining friends to help break her out: one his godson, a disgraced weatherman in the throes of a midlife crisis, and the other an ex-army marksman officially dead for forty years. On a tour bus once stolen from Paul McCartney, and joined by a young orphan boy searching for lost family, the band of misfits career towards Mississippi through a landscape of war, euthanasia, communism, religion and racism, and along the way discover the true meaning of love, family and - most important of all - friendship. If you loved The Unlikely Pilgrimage of Harold Fry and The Hundred Year-Old Man Who Climbed Out of the Window and Disappeared, you'll love J. Paul Henderson's Last Bus to Coffeeville!